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In postmarketing experience with ezetimibecases of myopathy and rhabdomyolysis have been reportedMost patients who developed rhabdomyolysis were taking a statin prior to initiating ezetimibeHoweverrhabdomyolysis has been reported with ezetimibe monotherapy and with the addition of ezetimibe to agents known to be associated with increased risk of rhabdomyolysissuch as fibric acid derivativesVYTORIN and a fenofibrateif taking concomitantlyshould both be immediately discontinued if myopathy is diagnosed or suspected.

Frequency not reportedEczematouspruritic rashtoxic epidermal necrolysisphotosensitivitypurpuraerythema multiformephotosensitivitypurpuraalopeciaRef]

Simvastatin is in a group of drugs called HMG CoA reductase inhibitorsorstatins

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at 1 year, the mean ldl-c was 26 lower in the simvastatin arm and 38 lower in the vytorin arm relative to placebo.

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