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The combination dose regimen was selected based on the tolerability profile of the 75 mg m 2 administered in 3-week cycles of docetaxel in combination with 1250 mg m 2 twice daily for 14 days of xeloda administered in 3-week cycles.

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The chemical name for capecitabine is 5deoxy-5-fluoro-Npentyloxycarbonylcytidine and has a molecular weight of 359.35Capecitabine has the following structural formula:

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficult breathingswelling of your facelipstongueor throat.

Have severe kidney problemsare allergic to capecitabine5-fluorouracilor any of the ingredients in XELODASee the end of this leaflet for a complete list of ingredients in XELODA.

Other than warfarinno formal drug-drug interaction studies between XELODA and other CYP2C9 substrates have been conductedCare should be exercised when XELODA is coadministered with CYP2C9 substrates.

Tell your doctor about all the medicines you takeincluding prescription and over-the-counter medicinesvitaminsand herbal supplementsXELODA may affect the way other medicines workand other medicines may affect the way XELODA works.

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as described below, patients taking xeloda should be informed of the need to interrupt treatment and to call their physician immediately if moderate or severe toxicity occurs.

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